肝癌缺失基因1(DLC-1)是一种新的肿瘤抑制基因,在人体许多正常组织中呈高表达,在多种肿瘤如肝癌、乳腺癌、食管癌、宫颈癌、鼻咽癌、结肠癌、霍奇金淋巴瘤中呈低表达或缺失,其与肿瘤的发生、发展及侵袭转移关系密切。DLC-1抗肿瘤的机制有两种:依赖Rho蛋白和不依赖Rho蛋白。现就DLC-1基因的结构及生物学功能,抗肿瘤机制及其意义进行综述。 Deletion of liver cancer gene 1 (DLC-1) is a novel tumor suppressor gene that is overexpressed in many human normal tissues and is widely expressed in many tumors such as liver cancer, breast cancer, esophageal cancer, cervical cancer, nasopharyngeal cancer, colon cancer , Hodgkin’s lymphoma was low expression or deletion, which is closely related with the occurrence, development and invasion and metastasis of the tumor. There are two mechanisms of anticancer activity of DLC-1: Rho-dependent and Rho-independent. Now on the structure and biological function of DLC-1 gene, anti-tumor mechanism and its significance are reviewed.