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目的探讨肺源性心脏病(PHD)急性加重期患者凝血纤溶系统的变化以及银杏叶提取物干预治疗的效果。方法 60例肺心病患者随机分为常规组和联合治疗组,每组各30例。两组常规治疗相同,治疗组每日再另加用舒血宁注射液20ml静滴,连用14d。并分别检测血浆凝血四项等指标的变化。结果临床疗效突出,住院时间缩短一周以上;治疗组纤维蛋白原(FBG)显著低于常规组(P<0.05)。治疗组和常规组治疗前后凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)比较无统计学差异。结论肺心病患者存在凝血纤溶系统失衡状态,舒血宁可改善血液高凝状态,并能减少住院天数。
Objective To investigate the changes of coagulation and fibrinolytic system in patients with acute exacerbation of pulmonary heart disease (PHD) and the effect of Ginkgo biloba extract. Methods Sixty patients with pulmonary heart disease were randomly divided into routine group and combination therapy group, 30 cases in each group. The same two groups of conventional treatment, the treatment group daily with Shuxuening injection 20ml intravenous infusion, once every 14d. And were detected four indicators of plasma coagulation changes. Results The clinical curative effect was prominent and the hospitalization time was reduced by more than one week. The fibrinogen (FBG) in the treatment group was significantly lower than that in the conventional group (P <0.05). Prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) in the treatment group and the conventional group had no significant difference before and after treatment. Conclusion Pulmonary heart disease in patients with coagulation and fibrinolytic system imbalance, Shuxuening can improve blood hypercoagulability, and can reduce the number of hospital days.