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目的为了探讨超声内镜胃癌分期与转移相关基因的关系。方法本文应用超声内镜(EUS)对73例胃癌患者进行术前分期,取内镜活检组织同步进行 p53、nm23、c-erbB2等基因蛋白产物的检测。结果肿瘤浸润达浆膜层后或有淋巴结转移的胃癌 p53、c-erbB2及复合表达率均明显增高,nm23单独表达在胃癌各期中无明显的统计学差异。结论提示胃癌转移相关基因表达与术前 EUS 分期有较好的相关性,并与浆膜层浸润及癌转移潜能密切关系,术前 EUS 检查尤应特别注意癌浸润是否已达浆膜层。
Objective To investigate the relationship between stage and gastric metastasis-related genes in endoscopic ultrasonography. Methods The preoperative staging of 73 patients with gastric cancer was performed by endoscopic ultrasonography (EUS). Endoscopic biopsy was performed to detect the protein product of p53, nm23, and c-erbB2. Results The p53, c-erbB2 and the compound expression rates of gastric cancer after tumor infiltration to the serosal layer or with lymph node metastasis were significantly higher, and there was no statistically significant difference in the expression of nm23 alone in gastric cancer. Conclusions suggest that there is a good correlation between the expression of metastasis-associated genes in gastric cancer and preoperative EUS staging, and it is closely related to serosal invasion and metastasis potential. In particular, preoperative EUS examination should pay particular attention to whether the cancer infiltration has reached the serosal layer.