磺脲类口服降糖药是治疗 2型ＤＭ(糖尿病 )的主要药物 ,临床应用非常广 ,但其继发失效的发生率 ,3%～ 30 %不等 ,年发生率约为 5 %～ 10 % ,连续用药 5年可达 4 0 %～ 5 0 % ;近来对磺脲类药继发性失效的治疗探讨了多种方案 ,均取得了较好的效果。本研究对四种不同的治疗方法进 Sulfonylurea oral hypoglycemic agents are the main drugs for the treatment of type 2 DM (diabetes), the clinical application is very wide, but the incidence of secondary failure ranging from 3% to 30%, the annual incidence of about 5% to 10 %, Continuous use of 5 years up to 40% ~ 50%; recently the treatment of secondary failure of sulfonylurea discussed a variety of programs, have achieved good results. The study of four different treatment methods into