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目的观察各型病毒性肝炎血清中主要特定蛋白（ＩｇＧ、ＩｇＡ、ＩｇＭ、Ｃ３、Ｃ４等）的变化及其临床意义。方法采用速率散射比浊法测定血清特定蛋白，并用ＥＬＩＳＡ法检测乙型肝炎核心抗体（ＩｇＧ、ＩｇＭ）。结果乙肝患者血清特定蛋白ＩｇＧ、ＩｇＡ、ＩｇＭ的上升幅度与病情严重程度相平行，即病情愈重，其含量愈高；但ＩｇＭ在急性肝炎病人升高并不明显，而且抗ＨＢＣ－ＩｇＭ特异性抗体对其含量的影响不大。补体Ｃ３、Ｃ４成分并不是所有肝病都呈下降趋势，且与病情的严重程度并不呈平行关系，但其下降与肝炎活动期或病毒持续感染有关。结论采用速率散射比浊法测定血清特定蛋白，有助于对临床肝病的病情评估、鉴别诊断及预后判断等。
Objective To observe the changes of major specific proteins (IgG, IgA, IgM, C3, C4, etc.) in various types of viral hepatitis and their clinical significance. Methods The specific protein of serum was determined by rate nephelometry and the core antibodies (IgG, IgM) of hepatitis B were detected by ELISA. Results The serum IgG, IgA and IgM in patients with hepatitis B increased in parallel with the severity of the disease, that is, the more serious the disease, the higher the content of IgM. However, IgM was not significantly elevated in patients with acute hepatitis, and the specificity of anti-HBC-IgM Antibodies have little effect on their content. Complement C3 and C4 components are not all downward trend in liver disease, and the severity of the disease does not show a parallel relationship, but its decline and hepatitis activity or persistent viral infection. Conclusion The speed-specific turbidimetric method for the determination of serum specific proteins is helpful for the assessment of clinical liver disease, differential diagnosis and prognosis.