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应用Ｔ细胞单克隆抗体检测了１４６例肝癌患者外周血Ｔ淋巴细胞亚群的分布，同时检测了ＮＫＣ、Ｌ—２活性，并结合日本肝癌研究会肝癌分期进行了分析。肝硬化组和ＣＤ３正常组相比无明显差别，而ＣＤ４、ＣＤ４／ＣＤ８明显下降，ＣＤ８明显上升；肝癌组ＣＤ４、ＣＤ４／ＣＤ８、ＣＤ８变化更明显，且与肝癌分期相关。肝癌组ＮＫｃ、ＩＬ─２活性也明显下降，提示按ＴＮＭ制定的肝癌分期不仅能反映肿瘤的发展情况，还可为临床评估患者免疫状态提供参考。
The distribution of T-lymphocyte subsets in peripheral blood of 146 patients with hepatocellular carcinoma was detected using monoclonal antibodies against T-cells. The activity of NKC and L-2 was also measured and analyzed in conjunction with the liver cancer stage of the Japanese Hepatic Cancer Research Society. There was no significant difference between the cirrhosis group and the normal group of CD3, but CD4, CD4/CD8 decreased significantly, and CD8 increased significantly. The changes of CD4, CD4/CD8, and CD8 were more obvious in the liver cancer group and were related to the staging of liver cancer. The activity of NKc and IL-2 in hepatocellular carcinoma was also significantly decreased, suggesting that the staging of liver cancer according to TNM not only reflects the development of the tumor, but also provides a reference for the clinical evaluation of the patient’s immune status.