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为探讨Ⅳ型胶原在糖尿病肾病中的意义 ,本文对 65例糖尿病患者及 2 5例正常人进行了血清Ⅳ型胶原 (IVC)及尿微量白蛋白排泄率 (UAER)测定 ,结果表明糖尿病病人血清IVC明显高于正常者 ,有微量蛋白尿及大量蛋白尿的糖尿病病人血清IVC水平除高于正常人外亦高于无蛋白尿糖尿病患者。IVC与UAER的相关分析 ,有显著相关性 (P <0 .0 1)。表明血清IVC与尿微量白蛋白一样可作为诊断糖尿病肾病的早期指标之一 ,阐明血清IVC发生机制可能与高血糖有关 ,长期、有效的控制血糖是积极防治糖尿病的重要措施
In order to explore the significance of type Ⅳ collagen in diabetic nephropathy, serum type Ⅳ collagen (IVC) and urine microalbumin excretion (UAER) were measured in 65 diabetic patients and 25 normal controls. The results showed that serums of diabetic patients IVC was significantly higher than normal, with microalbuminuria and a large number of proteinuria in patients with serum levels of serum IVC in addition to higher than normal, but also higher than those without proteinuria in patients with diabetes. There was a significant correlation between IVC and UAER (P <0.01). Serum IVC and urine microalbumin can be used as early diagnosis of diabetic nephropathy, one of the indicators to clarify the mechanism of serum IVC may be related to hyperglycemia, long-term and effective control of blood glucose is an important measure to actively prevent and treat diabetes