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目的探讨高胆红素血症新生儿血中内皮微粒与胆红素的关系及在疾病中的意义。方法 2009年10月至2011年2月中山大学附属一院新生儿科及产科住院的新生儿78例,根据有无黄疸分为试验组(44例)和对照组(34例),试验组中33例光疗治疗后采血分析。试验组光疗前、后采血行胆红素及内皮微粒测定,对照组采血行内皮微粒测定。结果试验组血内皮微粒光疗前为1792.0(574.5,2456.0)个/μL、光疗后为789.0(540.0,999.0)个/μL,与对照组414.0(321.8,866.0)个/μL比较,差异有统计学意义(P均<0.05)。试验组光疗前、后血内皮微粒比较,差异有统计学意义(P<0.05)。试验组光疗前、后血内皮微粒与血胆红素均成正相关(r分别=0.592、0.575,P<0.05)。结论高胆红素血症新生儿和非高胆红素血症新生儿相比,血内皮微粒显著升高,提示高胆红素可能对血管内皮造成损伤。
Objective To investigate the relationship between endothelial micro particles and bilirubin in neonates with hyperbilirubinemia and its significance in the disease. Methods From October 2009 to February 2011, 78 neonate neonates and obstetric patients hospitalized in the First Affiliated Hospital of Sun Yat-sen University were divided into experimental group (n = 44) and control group (n = 34) Cases of phototherapy after blood analysis. In the experimental group, bilirubin and endothelial micro-particles were collected before and after the phototherapy, while the control group were determined by the endothelial micro-particles. Results The number of blood endothelial cells in the experimental group was 1792.0 (574.5,2456.0) / μL before phototherapy and 789.0 (540.0,999.0) / μL after phototherapy, which was statistically different from the control group (414.0, 321.8, 866.0) / μL Significance (P <0.05). The difference between the experimental group and the control group was statistically significant (P <0.05). The experimental group before and after phototherapy blood endothelial cells and serum bilirubin were positively correlated (r = 0.592,0.575, P <0.05). Conclusions Compared with non-hyperbilirubinemia neonates, hyperbilirubinemia is significantly increased in serum endothelial cells, suggesting that hyperbilirubin may cause damage to vascular endothelial cells.