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目的分析早期联合检测血清糖化血红蛋白(血清HbA1c)和胱抑素-C(Cys-c)在诊断Ⅰ期糖尿病肾病(DN)的价值。方法选择120例确诊Ⅰ期糖尿病肾病患者作为DN组,同期120例健康人作为对照组,同时按照病程进行分A、B、C、D期,抽取晨起空腹静脉血行血清HbA1c和Cys-c含量检测。结果 DN组血清HbA1c和Cys-c水平明显高于对照组,差异具有显著性统计学意义(P<0.01);DN组内各期血清HbA1c和Cys-c水平与对照组比较,差异具有统计学意义(P<0.05)。结论早期联合检测血清糖化血红蛋白和胱抑素-C能够早期诊断Ⅰ期糖尿病肾病,为临床治疗提供参考依据,从而有效缩短治疗周期和提高生存质量。
Objective To analyze the value of early detection of serum glycated hemoglobin (HbA1c) and cystatin C (Cys-c) in the diagnosis of stage Ⅰ diabetic nephropathy (DN). Methods One hundred and twenty patients with diagnosed stage I diabetic nephropathy were selected as DN group and 120 healthy subjects were selected as control group. At the same time, the patients were divided into groups A, B, C and D according to their course of disease. The contents of serum HbA1c and Cys-c in fasting venous blood samples Detection. Results The levels of serum HbA1c and Cys-c in DN group were significantly higher than those in control group (P <0.01). The levels of serum HbA1c and Cys-c in DN group were significantly lower than those in control group Significance (P <0.05). Conclusion Early detection of serum glycated hemoglobin and cystatin-C can early diagnose stage I diabetic nephropathy and provide a reference for clinical treatment, thus effectively shortening the treatment cycle and improving the quality of life.