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目的，研究细胞团子对角膜成纤维细胞的生长作用，为细胞因子治疗角膜疾病的机制研究提供实验依据。方法：用MTF法测定细胞因子EGF、GTFF－β_1、FN等对角膜成纤维细胞生长的影响作用，结果：EGF对角膜成纤维细胞具有生长调节作用，在0.01~1.0μg/ml浓度下，具有明显促生长作用（与0浓度组比较P＜0．001），其最佳浓度为0．1μg/ml，但浓度在10.0μg／ml时却对其具有明显抑制作用（与0浓度组比较P＜0005），TGF－β_1（0.01－10.0ng/ml）、FM（0.01－10．0mg/ml）对角膜成纤维细胞未见明显促生长或抑制作用（P＞0.05）结论：EGF能调节角膜成纤维细胞生长，而TGF、FN对角膜成纤维细胞生长无影响，
Objective To study the growth of corneal fibroblasts and provide experimental evidence for the mechanism of cytokines in the treatment of corneal diseases. Methods: The effects of EGF, GTFF-β 1 and FN on the growth of corneal fibroblasts were determined by MTT assay. RESULTS: EGF had a regulative effect on the growth of corneal fibroblasts. At the concentration of 0.01-1.0 μg / ml, (P <0.001 compared with the 0 concentration group). The optimal concentration was 0.1μg / ml, but the concentration was inhibited at 10.0μg / ml (P (P0.01-10.0ng / ml) and FM (0.01-10.0mg / ml) did not significantly promote the growth and inhibition of corneal fibroblasts (P0.05) .Conclusion: EGF can regulate the cornea Fibroblasts, while TGF, FN had no effect on the growth of corneal fibroblasts,