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应用免疫组化技术对６０例胃癌组织中细胞周期素Ｄ１和Ｐ５３突变蛋白进行检测。结果３９例（６５０％）胃癌组织中细胞周期素Ｄ１表达阳性，３８（６３３％）例Ｐ５３突变蛋白表达阳性，细胞周期素Ｄ１和Ｐ５３蛋白弥漫阳性多见于分化差的胃癌。有淋巴结转移的３２例胃癌中２６例（８１２％）细胞周期素Ｄ１阳性，２５（７８１％）例Ｐ５３蛋白阳性（Ｐ＜００５）。提示细胞周期素Ｄ１和Ｐ５３蛋白共同异常表达属于胃癌发展和／或进展中的现象，在胃癌中评价细胞周期素Ｄ１的表达与Ｐ５３蛋白表达同样重要。
Immunohistochemical technique was used to detect the cyclin D1 and P53 mutant proteins in 60 gastric cancer tissues. RESULTS: The expression of cyclin D1 was positive in 39 cases (65.0%) of gastric cancer tissues, and the expression of P53 mutein was positive in 38 cases (63. 3%). The diffusely positive cyclin D1 and P53 proteins were more common in poorly differentiated gastric cancer. Thirty-six cases of gastric cancer with lymph node metastasis (81. 2%) were positive for cyclin D1, and 25 (78.1%) were positive for P53 protein (P<0. 05). It suggests that the common abnormal expression of cyclin D1 and P53 protein is a phenomenon in the development and/or progression of gastric cancer. The evaluation of the expression of cyclin D1 is as important as the expression of P53 protein in gastric cancer.