论文部分内容阅读
目的 探讨新生儿败血症菌株的变迁及药敏试验的临床意义。 方法 严格无菌操作,取双份血作血培养,血培养结果生长同一细菌列为分析对象。 结果 菌株分布第1位为葡萄球菌,占61.9%(65/105),其中凝固酶阴性的葡萄球菌占86.2%(56/65),凝固酶阳性的金黄色葡萄球菌占13.8%(9/65);第2位为链球菌,占10.5%(11/105);克雷伯氏菌占5.7%(6/105);大肠埃希氏菌占5.7%(6/105);绿脓杆菌占4.8%(5/105);枯草芽孢杆菌占3.8%(4/105);蜡样芽孢杆菌占1.9%(2/105);以及其它菌株占5.7%(6/105)。药敏试验结果示,细菌对有青霉素G、苯唑西林、氨苄青霉素和红霉素普遍不敏感,耐药率>50%,对头孢类的头孢唑林、头孢噻肟、头孢哌酮以及青霉素类的哌拉西林,阿米卡星,环丙沙星敏感性高,耐药率不超过21.0%。 结论 本组新生儿败血症患儿条件致病菌占绝大多数,其中表皮葡萄球菌占首位。抗生素选择时,头孢唑林、头孢噻肟、头孢哌酮以及哌拉西林可列为首选,然后,根据药敏结果进行调整,以提高疗效。
Objective To investigate the changes of neonatal sepsis strains and the clinical significance of drug susceptibility test. Methods Strict aseptic operation, take double blood for blood culture, the same bacteria as the analysis of the growth of blood culture results. Results Staphylococcus aureus was the first strain of Staphylococcus aureus, accounting for 61.9% (65/105), coagulase-negative Staphylococcus aureus accounted for 86.2% (56/65), coagulase-positive Staphylococcus aureus accounted for 13.8% (9/65 ); The second was streptococcus, accounting for 10.5% (11/105); Klebsiella accounted for 5.7% (6/105); Escherichia coli accounted for 5.7% (6/105); Pseudomonas aeruginosa 4.8% (5/105); Bacillus subtilis accounted for 3.8% (4/105); Bacillus cereus accounted for 1.9% (2/105); and other strains accounted for 5.7% (6/105). Susceptibility test results show that bacteria are generally insensitive to penicillin G, oxacillin, ampicillin and erythromycin, resistance rate> 50%, cephalosporins cefazolin, cefotaxime, cefoperazone and penicillin Piperacillin, amikacin, and ciprofloxacin were highly sensitive, and their resistance rates did not exceed 21.0%. Conclusion This group of children with neonatal sepsis conditions accounted for the vast majority of pathogens, of which Staphylococcus epidermidis accounted for the first place. Cefazolin, cefotaxime, cefoperazone, and piperacillin were the first choice for antibiotic selection, and then adjusted to increase efficacy based on susceptibility results.