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目的了解医院药物不良反应(ADR)发生的情况及一般规律。方法对大庆市人民医院2008-01-2009-12上报的127例ADR报告,按患者年龄、性别、给药途径、药品类别、ADR累及器官或系统及临床表现等进行统计分析。结果 127例ADR报告中涉及药品共12类63种,其中抗微生物药引发的ADR最多,有54例;其次是中药注射剂23例;静脉给药引发的ADR例数最多,有106例;以皮肤及其附件损害最为常见,有56例。结论临床应重视和加强ADR监测和上报工作,以减少或避免ADR的发生,促进临床合理用药,保证患者用药安全。
Objective To understand the occurrence and general rule of hospital adverse drug reaction (ADR). Methods A total of 127 ADR cases reported by Daqing People’s Hospital from January 2008 to December 2009 were statistically analyzed according to patient’s age, sex, route of administration, drug category, ADR involved organ or system and clinical manifestation. Results A total of 127 types of drugs were involved in 127 ADRs, of which 63 were ADRs caused by antimicrobials, followed by 53 cases of Chinese traditional medicine injection. The most ADRs were caused by intravenous administration, with 106 cases of ADR. And its accessories damage the most common, 56 cases. Conclusion Clinical should pay attention to and strengthen the work of ADR monitoring and reporting in order to reduce or avoid the occurrence of ADR, to promote clinical rational use of drugs and ensure the safety of patients.