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目的：观察鲑鱼降钙素对绝经后骨质疏松症疼痛的疗效。方法：对９６例骨质疏松症患者，应用 鲑鱼降钙素５０ Ｕ隔日肌注１次，连续１个月，后改用鲑鱼降钙素鼻喷剂每日２００ Ｕ持续半年。同时每日口服 元素钙１０００ｍｇ。结果：９６例患者用药后总有效率为９３．７％；疼痛改善时间最快治疗后４ｈ。治疗半年后腰 背痛积分平均值明显降低（Ｐ＜０．０５）。治疗前后骨代谢生化指标比较，血碱性磷酸酶、骨钙素升高；尿羟脯氨 酸／肌酐比值有明显降低（Ｐ＜０．０５）；而尿钙／肌酐比值无明显改变。结论：鲑鱼降钙素有较好的缓解骨质疏松 症患者的自发性和负重性骨疼痛。
Objective: To observe the effect of salmon calcitonin on postmenopausal osteoporosis pain. Methods: 96 cases of osteoporosis patients, the application of salmon calcitonin 50 U every other day intramuscular injection for 1 month, then use salmon calcitonin nasal spray daily 200 U for six months. At the same time daily oral calcium elemental 1000mg. Results: The total effective rate of 96 patients after treatment was 93.7%; the pain was improved 4h after the fastest time of treatment. After six months of treatment, the average score of low back pain was significantly lower (P <0.05). Before and after treatment of biochemical markers of bone metabolism, blood alkaline phosphatase, osteocalcin increased; urinary hydroxyproline / creatinine ratio was significantly lower (P <0.05); and urinary calcium / creatinine ratio had no significant change. CONCLUSIONS: Salmon calcitonin has a good response to spontaneous and weight-bearing bone pain in patients with osteoporosis.