近十五年来,抗肿瘤化合物细胞毒作用机制的研究已有很大进展。这些研究表明抗肿瘤化合物与 DNA 结合或作用,抑制 DNA 或 RNA 合成,抑制蛋白质合成,干扰膜功能或与微管相互作用。另外对人体肿瘤有疗效的一些抗肿瘤抗生素的细胞毒和治疗作用机制也已作了研究。即使对良性和恶性细胞都有抑制作用的这些抗肿瘤化合物很可能对人体某种肿瘤有疗效。 Nearly fifteen years, anti-tumor compounds cytotoxic mechanism of research has made great progress. These studies show that anti-tumor compounds bind or interact with DNA, inhibit DNA or RNA synthesis, inhibit protein synthesis, interfere with membrane function, or interact with microtubules. In addition, some cytotoxic and therapeutic mechanisms of antitumor antibiotics that have therapeutic effects on human tumors have also been studied. Even those antitumor compounds that have inhibitory effects on both benign and malignant cells are likely to be effective on some tumors in humans.