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在健康人血的T淋巴细胞中有具对IgG(T_G)或IgM(T_M)的Fc受体的细胞亚群已由玫瑰花结形成法所证实.已发现T_M细胞具有辅助细胞功能,而T_G细胞具有抑制细胞功能.有人曾考虑银屑病中曾发现的免疫异常是否可能与免疫反应调节缺陷,其中包括周围血中T_G及T_M细胞比例的改变有关.为此作者等应用玫瑰花结形成法及分级离心从淋巴细胞悬液中纯化T细胞.并用亚凝集量的兔IgG抗体致敏的公牛红细胞与新鲜分离的T淋巴细胞所致的玫瑰花结形成法确定T_G细胞.同时也用亚凝集量的兔IgM抗体所包被的公牛红细胞所致的玫瑰花结形成法确定T_M细胞(后一方法的玫
Cell subsets with Fc receptors for IgG (T_G) or IgM (T_M) have been confirmed by rosette formation in healthy human T lymphocytes T cells have been found to have helper cell functions whereas T_G Cells have inhibited cell function.It has been considered whether the immune abnormalities found in psoriasis may be related to the regulation of immune response defects, including the surrounding blood T_G and T_M cell ratio changes.To this end, the application of rosette formation method And fractionated by centrifugation to purify T cells from the lymphocyte suspension, and determine the T_G cells by rosetting with freshly isolated T lymphocytes induced by the sub-aggregated amount of rabbit IgG antibody.Meanwhile, The amount of rabbit IgM antibody coated rhesus erythrocyte rosetting method to determine T_M cells (the latter method of the rose