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目的探讨转化生长因子β１基因表达产物在人非小细胞肺癌中的表达水平及其临床意义。方法采用免疫组织化学方法对７３例人非小细胞肺癌组织中转化生长因子β１基因表达蛋白水平进行了研究。结果转化生长因子β１基因表达水平与肺癌的病期、组织学类型、细胞分化程度，以及肺癌转移有密切关系。转化生长因子β１基因表达水平在腺癌明显高于鳞癌和腺鳞癌，低分化癌明显低于中－高分化癌，Ⅲ、Ⅳ期癌明显低于Ⅰ、Ⅱ期癌，转移癌明显低于原发癌，有淋巴结转移的原发癌明显低于无淋巴结转移的原发癌（Ｐ＜０．０１或Ｐ＜０．０５）。结论转化生长因子β１基因参与调控肺癌的发生、发展和转移过程。
Objective To investigate the expression level of transforming growth factor β1 gene in human non-small cell lung cancer and its clinical significance. Methods Immunohistochemistry was used to study the expression of transforming growth factor-β1 gene in 73 cases of human non-small cell lung cancer. Results The expression level of TGF-β1 gene was closely related to the stage, histological type, cell differentiation, and metastasis of lung cancer. The expression of TGF-β1 gene in adenocarcinoma was significantly higher than that in squamous cell carcinoma and adenosquamous carcinoma. The poorly differentiated carcinoma was significantly lower than the moderately-differentiated carcinoma. The carcinomas of stage III and IV were significantly lower than those of stage I and II carcinomas. The metastatic carcinoma was significantly lower. In primary cancer, primary cancer with lymph node metastasis was significantly lower than primary cancer without lymph node metastasis (P<0.01 or P<0.05). Conclusion The transforming growth factor β1 gene is involved in the regulation of the occurrence, development and metastasis of lung cancer.