用放射免疫法测定25例窒息新生儿血清T_3、T_4、rT_3、TSH值,结果显示,与非窒息新生儿相比,窒息组血清T_3值明显降低(p<0.001),rT_3值明显升高(p<0.01),TSH值正常,窒息可以引起新生儿甲状腺功能改变。此改变与患儿性别、胎龄、体重无关,T_3、T_4值变化与窒息程度呈显著正相关,轻度窒息时T_3下降,T_4正常,重度窒息时除T_3明显降低外,T_4也多下降,T_4降低在窒息新生儿可提示疾病的严重程度。 Serum levels of T_3, T_4, rT_3 and TSH in 25 neonates with asphyxia were measured by radioimmunoassay. Compared with non-asphyxiated neonates, serum T_3 was significantly lower (p <0.001) and rT_3 was significantly higher in asphyxiated neonates p <0.01), TSH normal, asphyxia can cause neonatal thyroid function changes. The change of T_3 and T_4 was positively correlated with the degree of asphyxia, T_3 of mild asphyxia, T_4 of normal and severe asphyxia except T_3 decreased significantly, T_4 reduces the severity of illness that can be suggested in asphyxiated newborns.