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成百万发展中国家的小儿因胃肠道感染和营养不良致死。腹泻时口服或静脉补充液体和电解质十分有效,但这需要一定的设备。若有一种可减少腹泻时液体丧失的药物而该药价格低廉能普遍采用又无明显的副作用,对腹泻患者的治疗会有价值。实验证明治疗剂量的阿斯匹林能防止霍乱毒素所产生的分泌作用,没有霍乱毒素时阿斯匹林亦能增加小肠吸收水分。作者用鼠做实验发现阿斯匹林能减少大肠杆菌毒素(不耐热),葡萄球菌、克雷白氏菌、沙
Tens of millions of children in developing countries die of gastrointestinal infections and malnutrition. Diarrhea, oral or intravenous fluids and electrolytes is very effective, but this requires some equipment. If there is a kind of medicine that can reduce the loss of liquid when diarrhea and the low price of the drug can be widely used with no obvious side effects, it will be valuable for the treatment of diarrhea patients. Experiments show that the therapeutic dose of aspirin can prevent the secretion of cholera toxin secretion, in the absence of cholera toxin aspirin can also increase the intestinal absorption of water. The authors used mice to experiment found that aspirin can reduce E. coli toxins (heat-resistant), Staphylococcus, Klebsiella, sand