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目的：探索依那普利对慢性肾小球肾炎的疗效。方法：４４例慢性肾炎伴肾功能不全、持续性蛋白尿＞２．５ｇ／２４ｈ病人分成２组。治疗组２６例（男性１７例，女性９例；年龄３９±ｓ９ａ）采用依那普利１０～２０ｍｇ／ｄ，维持用药６ｍｏ。对照组１８例（男性１２例，女性６例；年龄３７±８ａ）给予降压药如硝苯地平等．２组病人均给予低蛋白（以优质蛋白为主）、低盐的限制性饮食．结果：依那普利组尿蛋白下降６５％±８％（Ｐ＜０．０１），优于对照组（Ｐ＜０．０１）；血肌酐和肾小球滤过率（ＧＦＲ）无明显变化（Ｐ＞０．０５）．，对照组尿蛋白亦减少（Ｐ＜０．０５），同时伴有血肌酐明显上升（Ｐ＜０．０１）和ＧＦＲ明显下降（Ｐ＜０．０１）。结论：依那普利有保护肾功能作用。
Objective: To explore the effect of enalapril on chronic glomerulonephritis. Methods: 44 cases of chronic nephritis with renal insufficiency, persistent proteinuria> 2.5g / 24h were divided into two groups. Treatment group, 26 patients (17 males and 9 females; age 39 ± s9a) enalapril 10 ~ 20mg / d, maintenance medication 6mo. Control group, 18 patients (12 males and 6 females; age 37 ± 8a) were given antihypertensive drugs such as nifedipine. Patients in both groups were given low-protein (mainly high-quality protein) and low-salt diet. Results: Urinary protein in enalapril group decreased by 65% ± 8% (P <0.01), which was better than that in control group (P <0.01). There was no significant change in serum creatinine and glomerular filtration rate (GFR) (P> 0.05). (P <0.05), accompanied by a significant increase of serum creatinine (P <0.01) and a significant decrease of GFR (P <0.01). Conclusion: Enalapril has renal function.