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无机砷既是一种毒物 ,又是一种抗癌药物。无机砷的许多作用机制与甲基化密切相关 ,无机砷的甲基化是其在人体内的主要代谢步骤之一 ;无机砷的致癌作用也与其引起基因的异常甲基化有关。本文对二者间的关系作一综述。
Inorganic arsenic is both a poison and an anti-cancer drug. Many mechanisms of inorganic arsenic are closely related to methylation. Methylation of inorganic arsenic is one of the major metabolic processes in human body. The carcinogenic effect of inorganic arsenic is also related to its abnormal methylation. This article reviews the relationship between the two.