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随着人们生活水平的不断提高,全球糖尿病发病率正在逐年增加,糖尿病周围神经病变(DPN)是糖尿病常见的并发症之一,其发病率是糖尿病人的40%～70%,我院对35例DPN患者应用弥可保(甲钴胺)治疗,取得满意疗效,现报告如下。临床资料1一般资料:我院自1998年8月～2010年6月入住的糖尿病病人,按符合WHO的诊断标准选例,均为2型糖尿病,年龄20～69岁,病程2～18年,平均5.8年。治疗组男16例,女19例;对照组男6例,女5例。选择条件为:(1)四肢自发性对称性疼痛和感觉障碍,并排除其他原因造成的神经病变;(2)呈手套袜筒样对称性痛觉障碍平面;(3)膝腱反射减弱或消失。2方法:所有病例均进行饮食控制,并根据病情选择应用降糖药物及胰岛素(单用或合用),治疗组用弥可保0.5mg肌注,1次/d,14天为1疗程。3疗效评定标准:显效:四肢感觉异常、麻木、疼痛完全消失;有效:四肢感觉异常、麻木、疼痛症状减轻50%以上;无效:四肢感觉异常、麻木、疼痛症状改善10%以下。4结果:治疗1疗程后上述症状明显改善的在60%以上,
With the continuous improvement of people’s living standards, the incidence of diabetes in the world is increasing year by year. Diabetic peripheral neuropathy (DPN) is one of the common complications of diabetes. The incidence of diabetes mellitus is 40% -70% Cases of DPN patients with methycobalamin (mecobalamin) treatment, and achieved satisfactory results, are as follows. Clinical data 1 General Information: In our hospital from August 1998 to June 2010 admitted to patients with diabetes, in line with the WHO diagnostic criteria for selection, are type 2 diabetes, aged 20 to 69 years, duration of 2 to 18 years, Average 5.8 years. Treatment group, 16 males and 19 females; control group, 6 males and 5 females. The conditions of selection were: (1) spontaneous symmetrical pain and sensory extremities, and exclusion of neuropathy caused by other causes; (2) a sock-like symmetrical pain-relief plane in the glove; and (3) a decrease or disappearance of the knee tendon reflex. 2 Methods: All cases were diet control, and according to the disease choose to use hypoglycemic agents and insulin (single or combined), the treatment group with intramuscular injection of miconazole 0.5mg, 1 / d, 14 days for a course of treatment. Effectiveness: limbs feel abnormal, numbness, pain relief more than 50%; invalid: limbs feel abnormal, numbness, the improvement of the pain symptoms less than 10%. 4 Results: After the treatment of a course of treatment significantly improved the above symptoms in more than 60%