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肝病同时发生肾功能衰竭之间的相互关系,一百多年前就有认识,但至今尚未完全阐明。今就肝硬化时的肾功能改变与急性肾功能衰竭的有关问题作一阐述。肾功能的病理生理改变一、肾钠潴留门脉性肝硬化时引起显著的钠潴留,细胞外液蓄积过多,临床上出现腹水与水肿。肝硬化病人排泄钠的能力减退,也可能与饮食中钠含量超过最大尿钠排泄有关,临床上见到限制钠盐摄取时,体重增加和腹水形成可减轻或停止。肝硬化时这种肾钠处理异常并不是固定不变的,因为多数病人坚持限制钠盐饮食制度后几天或1～2周内出现自发性利尿,且当肝硬化病人钠潴
The correlation between liver disease and renal failure occurs more than 100 years ago, but it has not yet been fully elucidated. Now on the cirrhosis of renal function changes and acute renal failure related to an elaboration. Pathophysiology of renal function changes First, sodium and sodium retention caused by portal hypertension Cirrhosis caused significant sodium retention, extracellular fluid accumulation, clinical ascites and edema. Patients with cirrhosis of the ability to excrete sodium decreased, may also be related to the sodium content in the diet exceeds the maximum urinary sodium excretion, clinically seen to limit sodium intake, weight gain and ascites can be reduced or stopped. This abnormality of renal sodium treatment during cirrhosis is not constant because most patients adhere to spontaneous diuresis within a few days or 1 to 2 weeks after restricting sodium diet, and when patients with cirrhosis have sodium retention