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控释制剂的生物利用度在口服后受胃肠道中不同区域转运的影响。有些药物在肠内的各区域都能很好地吸收;另一些药物在结肠难以吸收,仅小肠有所谓的“吸收窗”。如控释系统在胃内能保留一段时间,则剂型的生物利用度可增加或更易于预测。本研究系在正常受试者的胃内进行,以此来评价片剂和丸剂的漂浮系统是否比传统的非漂浮系统优越。制剂在胃内的情况由γ射线闪烁仪监控,使用两种放射性同位素以保证交叉研究(轻丸密度为0.94 g·cm~(-3),重
The bioavailability of the controlled release formulation is affected by the translocation of different regions of the gastrointestinal tract after oral administration. Some drugs are well absorbed in all areas of the intestine; others are difficult to absorb in the colon, and the so-called “absorption window” in the small intestine alone. If the controlled release system remains in the stomach for a period of time, the bioavailability of the dosage form may be increased or more predictable. This study was conducted in the stomach of normal subjects to evaluate whether tablets and pills are superior to traditional non-floating systems in their floating systems. The formulation in the stomach was monitored by a gamma-ray scintillator and two radioisotopes were used to ensure crossover studies (pellet density 0.94 g · cm -3, weight