目的　减少胰十二指肠切除术后并发症的发生率。方法　总结 4 5例胰十二指肠切除术 (PD)的经验并复习相关文献。结果　本组无一例发生术后腹腔内出血。本组胰液外引流 12例及胰管结扎后套入空肠 2例 ,无一例发生胰漏 ;而未置管或置管后远端放在空肠未引出肠外者 3 1例 ,发生胰漏 6例 ( 19.3 % )。 2例死于急性肾功能衰竭及呼吸系统并发症 ,手术死亡率为 4 .4 %。结论　充分的术前准备、细致的手术操作及合理地放置胰管引流管可以明显地减少胰十二指肠切除术后并发症 Objective To reduce the incidence of complications after pancreatoduodenectomy. Methods The experience of 45 cases of pancreatoduodenectomy (PD) was summarized and relevant literature was reviewed. Results None of this group occurred postoperative intraperitoneal hemorrhage. In this group, 12 cases of pancreatic juice drainage and pancreatic duct ligation into the jejunum in 2 cases, no case of pancreatic leakage occurred; without catheter or catheter distal to the jejunum did not lead to entero were 31 cases of pancreatic leakage occurred 6 Case (19.3%). 2 died of acute renal failure and respiratory complications, the operative mortality was 4. 4%. Conclusion Adequate preoperative preparation, meticulous surgical operation and reasonable placement of pancreatic duct drainage tube can significantly reduce complications after pancreatoduodenectomy