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选用1～3岁龄的猕猴(maca mulatta)15只(其中有2只对照)进行了戊型肝炎病毒(Hepatitis E virus简称HEV)的感染实验。第1代感染两批动物:第1批感染4只,3只发病;第2批感染4只,全部发病。后用第2批感染猴的粪便及肝脏悬液作为第1代,进行第2代感染。第2代感染4只猴,也全部发病,用肝悬液传代的1只猴也发病。感染后发病的猴血清丙氨酸转氨酶(ALT)水平均有不同程度的上升,一般高于正常值3～6倍,最高可10倍左右。肝活检可见肝细胞炎症和坏死。猴的粪便标本用免疫电镜(IEM)检测可见直径为27～34nm的病毒颗粒。
15 (1 males and 3 males), two of which were control, were infected with Hepatitis E virus (HEV). The first generation infected two batches of animals: the first batch of four infected, three onset; the second batch of four infected, all of the disease. After the second batch of infected feces and liver suspension of the monkey as the first generation, the second generation of infection. The second generation of four infected monkeys, also all the disease, the passage of the liver suspension of a monkey also disease. Infected monkeys serum alanine aminotransferase (ALT) levels have varying degrees of increase, generally higher than the normal 3 to 6 times, up to 10 times. Liver biopsy shows hepatocellular inflammation and necrosis. Monkey stool specimens with immunoelectron microscopy (IEM) detected the diameter of 27 ~ 34nm virus particles.