在1980年以前人们已经发现许多病人在开始接受普通胰岛素治疗后不久,体内就会产生抗胰岛素抗体。引起这种免疫反应的因素有很多,其中包括胰岛素的来源和纯度。1980年Heding等指出,主要的致免疫杂质 Before 1980, it was found that many patients developed anti-insulin antibodies in the body shortly after starting their usual insulin therapy. There are many factors that cause this immune response, including the source and purity of insulin. Heding and others pointed out in 1980 that the major immunogenic impurities