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本文报道一种分析羟基安定硬胶囊和软胶囊的RP-HPLC法.该法简易、专属、准确、快速和稳定性好,适用于羟基安定胶囊、羟基安定的有关前体和降解产物(5-氯-2-甲基氨基-二苯甲酮、3-乙酰氧基-7-氯-1-甲基-5-苯基-1,3-二氢-2H-1,4苯并二氮杂(艹卓)-2-酮和7-氯-1-甲基-5-苯基-4,5-二氢-2H-1,4-苯并二氮杂(艹卓)-2,3-二酮)的分析.色谱条件:使用由510型泵,可变波长检测器、自动进样器和图纸记录器组成的液相色谱仪,辛硅烷C_?
This paper reports an RP-HPLC method for the analysis of hydroxylamine hydrochloride hard capsules and soft capsules.The method is simple, specific, accurate, rapid and stable and suitable for the preparation of hydroxylamine hydrochloride capsules, the related precursors and degradation products of 5- Chloro-2-methylamino-benzophenone, 3-acetoxy-7-chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4 benzodiazepine 2-one and 7-chloro-1-methyl-5-phenyl-4,5-dihydro-2H-1,4-benzodiazepine-2,3 Dione) Chromatographic conditions: A liquid chromatograph consisting of a 510 pump, a variable wavelength detector, an autosampler and a chart recorder was used,