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目的:观察复方蜥蜴散不同微粒组合剂对慢性萎缩性胃炎(Chronic atrophic gastritis,CAG)模型大鼠血清PGE2及NOS水平的影响,探讨其胃黏膜保护作用机制。方法:将90只SD雄鼠随机分为正常组、模型组、复方蜥蜴散80目组、复方蜥蜴散100目组、复方蜥蜴散不同微粒组合剂(80目+100目)组及维酶素组。除正常组外,其余各组采取2%水杨酸、55℃热盐水经口灌胃,20mmoL/L脱氧胆酸钠自由饮用,配合饥饱失常造成CAG模型。治疗后4周,检测大鼠血清PGE2及NOS的水平。结果:复方蜥蜴散各不同微粒剂型治疗组大鼠PGE2水平明显高于模型组(P<0.01),NOS水平则低于模型组(P<0.01);复方蜥蜴散不同微粒组合剂组大鼠PGE2水平高于复方蜥蜴散80目组和100目组(P<0.01),NOS水平则低于复方蜥蜴散80目组和100目组(P<0.01);各治疗组胃黏膜病理表现明显好转。结论:复方蜥蜴散各不同微粒剂型均可改善CAG模型大鼠胃黏膜的病理情况,升高PGE2水平,降低NOS水平,发挥保护胃黏膜的作用;其中以复方蜥蜴散不同微粒组合剂疗效最佳。
OBJECTIVE: To observe the effect of different particulate composition of compound lizards on the serum PGE2 and NOS levels in rats with chronic atrophic gastritis (CAG) and to explore the mechanism of gastric mucosal protective effect. Methods: Ninety SD male rats were randomly divided into normal group, model group, compound lizards group of 80 eyes, compound lizards group of 100 eyes, compound lizards group of different particles (80 mesh +100 mesh) group. In addition to the normal group, the remaining groups to take 2% salicylic acid, 55 ℃ hot saline by oral gavage, 20mmoL / L sodium deoxycholate free to drink, with the lack of regularity caused CAG model. Four weeks after the treatment, serum PGE2 and NOS levels were measured. Results: The levels of PGE2 in the rats treated with different dosage forms were significantly higher than those in the untreated group (P <0.01), and those in the model group were significantly lower than those in the model group (P <0.01). PGE2 (P <0.01). The level of NOS was lower than that of compound lizards in Group 80 and Group 100 (P <0.01). The pathological changes of gastric mucosa in each group were significantly improved. Conclusion: Different dosage forms of compound lizards can improve the gastric mucosa pathological conditions, raise the level of PGE2, decrease the level of NOS in gastric mucosa of CAG rats, and play a role in protecting the gastric mucosa. Among them, the compound lizards with different particle combinations have the best curative effect .