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检测３４例急性白血病（ＡＬ）患者治疗前后ｖＷＦ：Ａｇ（Ｌａｕｒｅｌｌ免疫电泳法），ＴＭ（ＥＬＩＳＡ法）和ＥＴ（ＲＩＡ法）三种血管内皮细胞损伤分子标志物的变化。结果表明，ＡＬ治疗前ｖＷＦ，ＴＭ，ＥＴ均比正常对照组显著升高，ＡＮＬＬ和ＡＬＬ组间无明显差异。化疗完全缓解后，ＴＭ和ＥＴ恢复正常，ｖＷＦ也明显降低，但仍高于正常。复发患者ｖＷＦ、ＩＴＭ、ＥＴ又均显著升高。１３例非恶性血液病与正常组无明显差别。结果提示，此３种分子标志物可作为反映ＡＬ病情和监测疗效的有用指标，其在白血病时的病理生理作用值得进一步研究。
The changes of three molecular markers of vascular endothelial cell injury before and after treatment of 34 patients with acute leukemia (AL) before and after treatment were detected by Laurell immunoelectrophoresis, TM (ELISA) and ET (RIA). The results showed that before treatment, vWF, TM, and ET were significantly higher than those of the normal control group, and there was no significant difference between the ANLL group and the ALL group. After complete remission of chemotherapy, TM and ET returned to normal, vWF also decreased significantly, but still higher than normal. Relapsed patients had significantly higher vWF, ITM, and ET. There were no significant differences between 13 non-malignant hematologic diseases and normal subjects. The results suggest that these three molecular markers can be used as a useful indicator to reflect the condition of AL and monitor the efficacy, and its pathophysiological role in leukemia deserves further study.