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目的观察丹红注射液治疗不稳定型心绞痛(UAP)的疗效,及对炎症因子的影响。方法将70例UAP患者随机分为治疗组和对照组各35例。对照组给予阿司匹林、氯吡格雷、硝酸酯类、低分子肝素、β-受体阻滞剂、钙离子拮抗剂、他汀类药物等,治疗组在此基础上加用丹红注射液,1次/d。两组治疗均为2周,观察患者临床症状改善情况及血清高敏C-反应蛋白(hs-CRP)水平。结果治疗后治疗组和对照组的总有效率分别为91.43%和65.71%,治疗组明显优于对照组(P<0.01)。两组患者hs-CRP较治疗前明显下降,治疗组更为明显(P<0.01)。治疗组在用药过程中未见不良反应。结论丹红注射液显著改善不稳定型心绞痛患者的临床症状,并能抑制炎性反应,防止斑块破裂,是辅助治疗不稳定型心绞痛的一种安全有效的药物。
Objective To observe the curative effect of Danhong injection on unstable angina pectoris (UAP) and its effect on inflammatory factors. Methods 70 patients with UAP were randomly divided into treatment group and control group of 35 cases. The control group was given aspirin, clopidogrel, nitrates, low molecular weight heparin, β-blockers, calcium antagonists, statins, etc. On the basis of this, the treatment group was given Danhong injection once / d. The two groups were treated for two weeks, and observed the clinical symptoms and serum high-sensitivity C-reactive protein (hs-CRP) levels. Results After treatment, the total effective rates of the treatment group and the control group were 91.43% and 65.71%, respectively, and the treatment group was significantly better than the control group (P <0.01). Hs-CRP in both groups was significantly lower than before treatment, the treatment group was more obvious (P <0.01). The treatment group in the medication process no adverse reactions. Conclusion Danhong injection can significantly improve the clinical symptoms of patients with unstable angina and can inhibit the inflammatory response and prevent rupture of plaque. It is a safe and effective drug for the treatment of unstable angina pectoris.