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目的:探讨HPV感染与宫颈病变的关系。方法:对2008年2月-2009年3月期间在通山县人民医院皮肤性病科和妇科门诊就诊的1256位女性的宫颈拭子标本进行HPV DNA实时荧光定量PCR检测,比较不同宫颈病变级别组HPV的阳性率。结果:各病变组与正常组比较差异有显著性,P<0.01,且随病变级别增加总阳性率逐渐上升。结论:HPV在人群具有较高的感染率,且HPV感染与宫颈病变的发生有关。实时荧光定量PCR检测HPV DNA可成为一种广泛应用的临床检验技术,作为筛查宫颈癌及癌前病变的首选方法。
Objective: To investigate the relationship between HPV infection and cervical lesions. Methods: A total of 1256 female cervical swab specimens from the Department of Dermatology and Gynecology Clinic of Tongshan People’s Hospital from February 2008 to March 2009 were detected by real-time fluorescent quantitative polymerase chain reaction (PCR) and HPV DNA level in different cervical lesions HPV positive rate. Results: There was a significant difference between each group and the normal group (P <0.01), and the positive rate increased with the increase of the grade. Conclusion: HPV has a high infection rate in the population, and HPV infection is related to the occurrence of cervical lesions. Real-time fluorescent quantitative PCR detection of HPV DNA can become a widely used clinical testing technology, as a screening method for cervical cancer and precancerous lesions of choice.