论文部分内容阅读
Survivin是抑制凋亡蛋白基因家族(IAP)的一员,表达于正常胎儿的形成过程,同时广泛表达于人类肿瘤。在肿瘤细胞的增殖发展过程中,对凋亡的调节可能起决定性作用,也对肿瘤进展产生很大影响。该研究的目的是观察Survivin在骨肉瘤细胞中的表达并作为预后评价指标的价值。40例骨肉瘤标本来源于14名女性,26名男性,平均年龄23岁(7～68岁)。标本经福尔马林固定,石蜡包埋。所有病例都经组织活检确诊并进行针对性辅助化疗和手
Survivin is a member of the inhibitor of apoptosis protein gene family (IAP), expressed in normal fetal formation, while widely expressed in human tumors. In the process of tumor cell proliferation and development, the regulation of apoptosis may play a decisive role, but also have a great impact on tumor progression. The purpose of this study was to investigate the expression of Survivin in osteosarcoma cells and to evaluate the prognostic value. 40 cases of osteosarcoma specimens from 14 females, 26 males, mean age 23 years (7 to 68 years). Specimens were fixed with formalin and embedded in paraffin. All cases were confirmed by biopsy and targeted adjuvant chemotherapy and hand