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目的了解深圳地区艾滋病病人抗病毒治疗的现状,为进一步开展规范化抗病毒治疗提供科学依据。方法对深圳市第三人民医院爱心门诊的174名参加免费抗病毒治疗的艾滋病患者进行横断面调查,对其治疗前后的各项指标进行统计分析。结果174例病人在抗病毒治疗1年后,98.2%的病人血浆中HIV-RNA载量下降到500拷贝/ml以内,CD4淋巴细胞计数平均上升137个/mm3。在抗病毒治疗过程中,有70例(40.2%)合并其他慢性感染,有150例(86.2%)分别出现不同程度的药物不良反应,更改治疗方案者82例(47.1%)。结论现有抗病毒治疗对艾滋病病人的疗效显著。在抗病毒治疗过程中,应注意监测药物的不良反应和合并其他慢性感染,以避免增加或加重药物的不良反应,在治疗上应严格规范化管理,最大限度地杜绝耐药的产生。
Objective To understand the status of anti-virus treatment for AIDS patients in Shenzhen and provide scientific basis for further standardization of anti-virus treatment. Methods A total of 174 AIDS patients participating in free antiviral therapy in Third People’s Hospital of Shenzhen City were surveyed by cross-sectional survey, and the indicators before and after treatment were statistically analyzed. Results In 174 patients one year after anti-virus therapy, the HIV-RNA load in plasma decreased to 500 copies / ml in 98.2% of patients, and the average CD4 lymphocyte count increased by 137 cells / mm3. During anti-virus treatment, 70 cases (40.2%) had other chronic infections, and 150 cases (86.2%) had different degrees of adverse drug reactions, and 82 cases (47.1%) changed treatment regimens. Conclusion The current antiviral therapy has a significant effect on AIDS patients. In the process of antiviral therapy, we should pay attention to monitoring adverse drug reactions and other chronic infections, in order to avoid increasing or exacerbating adverse drug reactions, the treatment should be strictly standardized management, to minimize the emergence of drug resistance.