原发性血小板减少性紫癜(下称ITP)是一种常见的出血性疾病,90%病人的血清中存有抗血小板抗体,用皮质激素治疗有效,其中仅20%能持续缓解.皮质激素治疗无效的病例,约80%对切脾有效,但其中30%病例通常在12个月内复发.我们于1988年5月～1989年10月用载有三尖杉酯碱或长春新碱的血小板治疗9例难治型ITP,取得了较好的疗效,现报告如下. Primary thrombocytopenic purpura (hereinafter referred to as ITP) is a common hemorrhagic disease, anti-platelet antibodies are present in sera of 90% of patients and are effective with corticosteroids, of which only 20% sustained relief. Approximately 80% of splenectomies are effective in splenectomy, but 30% of them usually recur within 12 months.We treated platelets with harringtonine or vincristine from May 1988 to October 1989 9 cases of refractory ITP, and achieved good results, are as follows.