肾病综合征出血热(HFRS)病人发生肺水肿的原因迄今尚未清楚。作者在近7年内观察到8例,其中男性7例,女性1例,平均年龄35.5±5.1岁。诊断经血清学检查证实,并均属第1血清型。查体时注意到特有的血管壁渗透性增高的症状:面、颈和上胸部充血、虚肿,软颚出血性内疹、爽痛症阳性、躯干侧面及腋下大量出血癌。肺水肿均发生于疾病的第6～10天,平均7.60±0.5天。仅2例有因过量摄食或输液而致病的基础。其临床表现与左室功能不全引起者相似,肺水肿发生后均经保守治疗无效而采用人工肾体外透析超滤治疗,其中死亡2例。对7例病人测定了全血和血浆组胺及血清素含量,全血组胺和血清素浓度分别较对照组增高0.5和3.6倍,血浆游离胺和血清素生理活性分别较对照组增高2.6和2倍,血清 The causes of pulmonary edema in patients with nephrotic syndrome hemorrhagic fever (HFRS) are not yet known. In the past seven years, the authors observed 8 cases, including 7 males and 1 females, with an average age of 35.5 ± 5.1 years. Serum confirmed by serological examination, and are the first serotypes. Physical examination noted the unique vascular wall permeability increased symptoms: face, neck and upper chest congestion, emphysema, soft jaw hemorrhagic rash, cool pain positive, a large number of side torso and armpit bleeding. Pulmonary edema occurred in the first 6 to 10 days, with an average of 7.60 ± 0.5 days. Only 2 patients had the basis of over-feeding or infusion disease. Its clinical manifestations and left ventricular dysfunction caused by similar, after the occurrence of pulmonary edema were conservative treatment ineffective and artificial renal dialysis ultrafiltration treatment, of which 2 patients died. Whole blood and plasma histamine and serotonin levels were measured in seven patients. Whole blood histamine and serotonin concentrations were 0.5 and 3.6 fold higher than those in the control group, respectively, and plasma free amine and serotonin levels increased 2.6 and 2 times, serum