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目的探讨Y染色体异常对男性生殖及发育的影响。方法常规外周血淋巴细胞培养,制备染色体标本,G显带,镜下核型分析。结果检出Y染色体异常104例,包括5种核型,主要表现为不良孕产史、无精子症、性别畸形、智力低下等。结论人类Y染色体变异通常会导致男性发育异常或生殖异常等遗传效应。
Objective To investigate the effect of Y chromosome abnormalities on male reproductive and development. Methods Routine peripheral blood lymphocyte culture, preparation of chromosome specimens, G band, microscopic karyotype analysis. Results Y chromosome abnormalities were detected in 104 cases, including five karyotypes, which were mainly manifested as poor history of pregnancy, azoospermia, gender deformity, mental retardation and so on. Conclusion Human Y chromosome variation usually leads to genetic effects such as male developmental abnormalities or reproductive abnormalities.