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目的:总结郎格罕细胞组织细胞增生症(LCH)的诊治经验。方法:对24例郎格罕细胞组织细胞增生症临床资料进行分析。结果:诊断为勒雪氏病(LS)16例,韩雪柯氏综合征(HSC)2例,骨嗜酸性肉芽肿(EGB)4例,难分型者2例。同时具临床、X线片和病理诊断者16例(占667%),诊断后给予放、化疗。3例死亡,5例放弃治疗,7例好转出院后失访,4例自动出院,5例坚持治疗至疗程结束,随访至今无复发。结论:重视临床表现尤其特征性皮疹并常规做皮疹印片,充分认识X线典型改变,有助于早期诊断;早期、联合、足量化疗辅以手术、放疗可改善预后。VEP(V为长春新碱,E为足叶乙甙,P为强的松)方案疗效好,副反应轻,值得推广
Objective: To summarize the diagnosis and treatment of Langerhans cell histiocytosis (LCH). Methods: The clinical data of 24 cases of Langerhans cell histiocytosis were analyzed. Results: 16 cases were diagnosed as Lech ’s disease (LS), 2 cases were Hankinson’ s disease (HSC), 4 cases were bone eosinophilic granuloma (EGB) and 2 cases were difficult to differentiate. At the same time with clinical, X-ray and pathological diagnosis in 16 cases (667%), after giving radiotherapy and chemotherapy. Three patients died, five gave up treatment, seven were lost and were discharged after discharge. Four patients were discharged spontaneously and five patients were persisted until the end of treatment. No recurrence was observed up to now. Conclusion: It is helpful to diagnose the early diagnosis of rashes, especially the characteristic rashes and the routine printing of rashes. It is helpful for the early diagnosis of patients with early diagnosis. The combination of early chemotherapy and adequate chemotherapy can improve the prognosis. VEP (V is vincristine, E is etoposide, P is prednisone) program efficacy, side effects, it is worth promoting