目的 :探讨糖尿病微血管病变对骨密度及骨钙素水平的影响。方法 :选择 2型糖尿病患者 60例 ,按其是否合并糖尿病微血管病 (眼病、肾病、神经病变 )分为两组 ,合并微血管病 (1组 ) 3 3例 ,不合并微血管病 (2组 ) 2 7例。用生化法测定两组的空腹血糖 (FBG)、果糖胺 (GSP)、血清总碱性磷酸酶 (TALP)及血钙 (Ca2 +) ,RIA测定骨钙素 (BGP) ,DEXA法测定腰椎和髋部骨密度 (BMD) ;按其身高、体重计算体重指数 (BMI)。结果 :两组BMI、GSP、FBG、TALP及Ca2 +均未见明显差异 ;1组血清BGP水平明显低于 2组 ,有显著性差异 ;1组第 2 - 4腰椎 (L2 -4)、股骨颈、Ward’s三角区及股骨大转子的BMD均低于 2组 ,差异有显著性。结论 :骨密度及骨钙素与糖尿病微血管病变关系密切。认为糖尿病微血管病可能降低骨形成 ,加重骨质疏松 Objective: To investigate the effect of diabetic microangiopathy on bone mineral density and osteocalcin. Methods: Sixty patients with type 2 diabetes mellitus were divided into two groups according to whether they had diabetic microangiopathy (ophthalmopathy, nephropathy, neuropathy). There were 33 cases with microangiopathy (group 1) and 2 cases without macroangiopathy 7 cases. The levels of fasting blood glucose (FBG), fructosamine (GSP), serum total alkaline phosphatase (TALP) and calcium (Ca2 +) were measured by biochemical methods. BGP and DEXA Hip bone mineral density (BMD); body mass index (BMI) based on their height and weight. Results: There was no significant difference in BMI, GSP, FBG, TALP and Ca2 between the two groups. Serum BGP level in group 1 was significantly lower than that in group 2, and there was a significant difference between group 1 and group 2 - 4 lumbar spine (L2 -4) The BMD of neck, Ward’s triangle area and femur greater trochanter were lower than those of the two groups, the difference was significant. Conclusion: Bone mineral density and osteocalcin are closely related to diabetic microangiopathy. It is thought that diabetic microangiopathy may reduce bone formation and aggravate osteoporosis