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目的动态观察３０例脑出血患者血浆内皮素－１（ＥＴ－１）、Ｐ物质（ＳＰ）含量变化。方法应用放射免疫分析法（ＲＩＡ）。结果（１）急性期血浆ＥＴ－１、ＳＰ含量显著高于对照组。（２）急性期血浆ＥＴ－１、ＳＰ含量显著高于恢复期。（３）急性期血浆ＥＴ－１含量与ＳＰ含量呈正相关。结论ＥＴ－１、ＳＰ共同参与和影响脑出血的病理生理过程，血浆ＥＴ－１、ＳＰ含量的增高在一定程度上反映了脑出血的严重程度
Objective To observe the changes of plasma endothelin-1 (ET-1) and substance P (SP) in 30 patients with cerebral hemorrhage. Methods Radioimmunoassay (RIA) was used. Results (1) The plasma levels of ET-1 and SP in acute phase were significantly higher than those in control group. (2) The plasma levels of ET-1 and SP in acute phase were significantly higher than those in recovery phase. (3) Acute phase of plasma ET-1 content and SP content was positively correlated. Conclusion ET-1 and SP participate in and influence the pathophysiological process of cerebral hemorrhage. The increase of ET-1 and SP in plasma reflects to some extent the severity of cerebral hemorrhage