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现代分子生物学研究证实,机体的细胞功能——从增殖到复杂的免疫学反应,均与相应的某些细胞因子调节相关,其中白细胞介素_2(IL_2)具有重要作用。IL_2的调节效应依赖于体内T 淋巴细胞、部分B 细胞和单核细胞细胞膜上表达的IL_2受体,这种可溶性IL_2受体(SIL_2R)可用专一性单克隆抗体(如抗Tac)检出,其生化性质与生物学功能已有Greene 等详述,国内亦有介绍。IL_2R 是一种由两条肽链(α、β)组成的糖蛋白,SIL_2R 分子量45KDa,小于其细胞膜上者(55KDa)。T 细胞抗原受体被有丝分裂原刺激后四小时内,开始表达SIL_2R,两天后上升至高峰,每个细胞的峰值可达6000位点,5～7天逐渐下降,最后出现不应期,此时对
Modern molecular biology studies have confirmed that the body’s cellular functions - from proliferation to complex immunological reactions, are related to the regulation of certain cytokines, with interleukin-2 (IL-2) playing an important role. The regulatory effect of IL-2 depends on IL-2 receptor expressed on T lymphocytes, some B cells and monocytes in vivo. SIL_2R can be detected by specific monoclonal antibody (such as anti-Tac) Its biochemical properties and biological functions have been described in detail Greene, also introduced in China. IL_2R is a glycoprotein composed of two peptide chains (α, β). The molecular weight of SIL_2R is 45 kDa, which is smaller than that of the cell membrane (55 kDa). T cell antigen receptor within 4 hours after being stimulated by mitogen began to express SIL_2R and rose to the peak after two days. The peak value of each cell reached 6000, gradually decreased from 5 to 7 days, and finally refractory period occurred. At this time Correct