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目的观察和评价氯沙坦临床疗效和耐受性。方法：共收治轻、中度高血压患者６０例，经停用其它降压药物２周后给予氯沙坦５０－１００ｍｇ每日一次治疗，每周测量血压及心率，并在治疗前后进行２４ｈ动态心电图及动态血压监测。结果：经８周治疗，患者ＳＢＰ／ＤＢＰ平均下降了１６．８±７７／９．０２±６．５３ｍｍＨｇ．与治疗前比较差异有显著性，总有效率７８．５％。２４ｈＡＢＰｍ显示 ２４平均 ＳＢＰ／ＤＢＰ较前下降，ＳＢＰ及 ＤＢＰ的Ｔ／Ｐ比值分别为５８．７％及６４．６％， ＳＤＮＮ、ＳＤＡＮＡ较治前升高。结论： Ｉｏｓａｒｔａｎ每日一次可有效控制血压，耐受性好。
Objective To observe and evaluate the clinical efficacy and tolerability of losartan. Methods: A total of 60 patients with mild to moderate hypertension were treated with losartan 50-100 mg twice daily after other antihypertensive drugs were discontinued. Blood pressure and heart rate were measured weekly and before and after treatment for 24 h ECG and ambulatory blood pressure monitoring. RESULTS: After 8 weeks of treatment, SBP / DBP decreased by an average of 16.8 ± 77 / 9.02 ± 6.53mmHg. Compared with the pre-treatment difference was significant, the total effective rate 78.5%. 24hABPm showed 24 mean SBP / DBP decreased compared with the previous, SBP and DBP T / P ratio was 58.7% and 64.6%, SDNN, SDANA increased compared with pre-treatment. Conclusion: Iosartan can effectively control blood pressure once a day and is well tolerated.