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Objective To explore the roles of MircroRNA-217(Mir-217),silent information regulator 1(Sirt1),and hypoxia-inducible factor-1α(HIF-1α)in high glucoseinduced inflammation and fibrosis in rat glomerular mesangial cells(RMCs).Methods RMCs were pre-incubated with a Sirt1 activator resveratrol prior to high glucose treatment or transfected with Sirt1 small interfering RNA
Objective To explore the roles of MircroRNA-217 (Mir-217), silent information regulator 1 (Sirt1), and hypoxia-inducible factor-1α (HIF-1α) in high glucose induced inflammation and fibrosis in rat glomerular mesangial cells (RMCs). Methods RMCs were pre-incubated with a Sirt1 activator resveratrol prior to high glucose treatment or transfected with Sirt1 small interfering RNA