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应用图像分析技术和形态计量学方法，测量了１３１Ⅰ、１３２Ⅰ注入后２０月大鼠甲状腺组织损伤体视学参数的变化。结果表明，各剂量组胶体和滤泡的体积密度及表面积密度均明显小于对照组，且随着吸收剂量的增大逐渐减小（Ｐ＜００１）；间质的体积密度则随着剂量的增大而明显增大（Ｐ＜００１）；胶体的半径、体积和表面积随剂量的增大而明显变小；１３１Ⅰ、１３２Ⅰ各剂量组胶体半径的频率或概率分布的峰值均随照射剂量的增大而明显左移，即分布范围变窄，胶体的最大半径Ｘｍａｘ和期望值Ｅ（ｘ）显著变小。上述结果说明，胶体或滤泡的体积变小萎缩。用体积密度、表面积密度、胶体平均半径、体积和表面积等参数与吸收剂量的回归方程式计算出的半减或半增剂量Ｄ５０造成此相同效应１３１Ⅰ所需剂量为１３２Ⅰ的７～２６倍；因而，以１３１Ⅰ作为参考辐射造成此生物终点的１３２Ⅰ的相对生物效应（ＲＢＥ）为７～２６。
Image analysis and morphometric methods were used to measure the changes of visual acuity of thyroid tissue in rats after 131I and 132I injection. The results showed that the bulk density and surface area density of colloidal and follicular in each dose group were significantly smaller than those in control group, and decreased with the increase of absorbed dose (P <001). The bulk density of interstitial increased with dose (P <001). The radius, volume and surface area of the colloid obviously decreased with the increase of the dose. The peaks of the frequency or probability distribution of the colloid radius in each dose of 131Ⅰ, Dose of the obvious shift to the left, that the distribution of narrowing, the maximum colloidal radius Xmax and expected value E (x) significantly smaller. The above results show that the volume of colloidal or follicular smaller atrophy. This same effect is caused by the half-dose or half-dose D50, which is calculated from the regression equations of bulk density, surface area density, average colloid radius, volume and surface area, and absorbed dose, and the required dose for 131 I is 7 to 26 times higher than for 132 I; The relative bioeffect (RBE) of 132 I resulting in 131 I as the reference radiation was 7-26.