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目的探讨miR-126 rs4636297 G>A基因多态性与冠心病遗传易感的关系。方法利用聚合酶链式反应-连接酶检测反应(PCRLDR)分析技术,对563例冠心病患者和646例对照个体的miR-126 rs4636297 G>A多态位点进行分型,采用非条件逻辑回归分析该多态位点与冠心病易感的相关性。结果 AA、AG、GG基因型在冠心病组中的分布频率分别为2.1%、22.6%和75.3%,在对照组中分别是1.7%、25.4%和72.9%,两组间基因型频率分布无统计学差异(χ2=1.525,P=0.466)。携带miR-126 rs4636297 A变异等位基因与冠心病的遗传易感无明显相关性(OR=0.92,95%CI=0.73~1.16,P=0.484)。结论 miR-126 rs4636297 G>A多态位点与华南地区冠心病易感无相关性。
Objective To investigate the relationship between miR-126 rs4636297 G> A polymorphism and susceptibility to coronary heart disease. Methods Polymorphisms of miR-126 rs4636297 G> A in 563 patients with coronary heart disease and 646 controls were genotyped by polymerase chain reaction-ligase assay (PCRLDR), using non-conditional logistic regression Analysis of the polymorphism site and coronary heart disease susceptibility correlation. Results The distribution frequencies of AA, AG and GG genotypes were 2.1%, 22.6% and 75.3% in the CHD group and 1.7%, 25.4% and 72.9% in the control group respectively. There was no significant difference in genotype distribution between the two groups Statistical difference (χ2 = 1.525, P = 0.466). There was no significant correlation between the mutation of miR-126 rs4636297 A and the susceptibility to coronary heart disease (OR = 0.92, 95% CI = 0.73-1.16, P = 0.484). Conclusion The polymorphism of miR-126 rs4636297 G> A is not associated with coronary heart disease in southern China.