核因子-κB是一类具有多向活性的转录调控因子,参与多种基因的表达和调控,在机体的免疫应答、炎症反应、细胞生长分化和凋亡等方面起着重要作用。近年来的研究显示核因子-κB在幽门螺杆菌相关性胃炎的发生发展中起着重要的介导作用。此文重点介绍核因子-κB的结构和激活机制,及其在幽门螺杆菌相关性胃炎中的表达及可能的作用机制。 Nuclear factor-kappa B (NF-κB) is a type of transcriptional regulator with multi-directional activity. It is involved in the expression and regulation of many genes and plays an important role in the immune response, inflammatory response, cell growth and differentiation and apoptosis. In recent years, studies have shown that nuclear factor-κB plays an important mediating role in the development of Helicobacter pylori-associated gastritis. This article focuses on the structure and activation of nuclear factor-κB, and its expression in Helicobacter pylori-associated gastritis and its possible mechanism.