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目的:研究沐舒坦治疗新生儿胎粪吸入综合征的临床疗效,为新生儿胎粪吸入综合征的临床治疗提供依据。方法:收集胎粪吸入综合征新生儿96例,将患者按随机数字表法分为观察组和对照组,对照组患儿予以清除呼吸道等综合治疗,观察组在对照组治疗基础上加用沐舒坦雾化吸入治疗,比较两组患者治疗后的临床疗效、肺部啰音消失时间、氧疗时间、呼吸机使用时间、住院时间、并发症发生及死亡情况。结果:观察组治疗总有效率为95.83%,明显高于对照组的72.92%(P<0.05)。观察组湿啰音消失时间、氧疗时间、呼吸机使用时间、住院时间分别为(1.76±0.23)天、(7.02±2.17)天、(3.27±1.44)天、(4.68±2.11)天,均明显短于对照组(P<0.05)。观察组患儿并发症发生率、死亡率分别为6.25%、2.08%,对照组分别为33.33%、16.67%。观察组并发症发生率及死亡率均明显低于对照组(P<0.05)。结论:沐舒坦雾化吸入用于治疗新生儿胎粪吸入综合征时可明显提高疾病治疗的临床疗效,缩短肺部啰音消失时间、氧疗时间、呼吸机使用时间及住院时间,降低并发症发生率及死亡率。
Objective: To study the clinical efficacy of mucosolvan in the treatment of neonatal meconium aspiration syndrome and to provide the basis for the clinical treatment of neonatal meconium aspiration syndrome. Methods: Ninety-six newborn infants with meconium aspiration syndrome were collected. The patients were divided into observation group and control group according to random number table method. The control group was given comprehensive treatment of removing respiratory tract. The observation group was treated with control group Sultanate inhalation therapy, the clinical efficacy of the two groups of patients after treatment, the disappearance of pulmonary rales time, oxygen therapy time, ventilator time, hospital stay, complications and death. Results: The total effective rate of the observation group was 95.83%, which was significantly higher than that of the control group (72.92%, P <0.05). (1.76 ± 0.23) days, (7.02 ± 2.17) days, (3.27 ± 1.44) days and (4.68 ± 2.11) days respectively in the observation group, and the mean duration of oxygen therapy, oxygen therapy time, ventilator use time and hospital stay Significantly shorter than the control group (P <0.05). The incidence of complication and mortality in the observation group were 6.25% and 2.08% respectively, while those in the control group were 33.33% and 16.67% respectively. The incidence of complications and mortality in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: Mucosolvan inhalation for the treatment of neonatal meconium aspiration syndrome can significantly improve the clinical efficacy of disease treatment, shorten the pulmonary rales disappear time, oxygen therapy time, ventilator time and hospital stay, reduce complications Incidence and mortality.