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临床和实验室观察提示,对活化补体起反应的多形核粒细胞(PMN)的聚集可成为白细胞栓子留于肺内引起肺功能障碍,促使成人发生呼吸窘迫综合征(ARDS)。在补体活化的血浆中能检测到聚集的 PMN活性,后者能反映 C_(5a)浓度。作者研究了61例患者。每例均患有非胸部的重伤、霉菌血症、革兰氏阴性菌血症或低血压持续2小时以上,取血测定 PMN 的聚合作用。结果 61例中33例发生 ARDS。所观察的危险比率为0.54,易患 ARDS 的危险因素有:脓毒症、低血压、外伤、药物中毒和烧伤等。在血浆 PMN 聚
Clinical and laboratory observations suggest that the aggregation of polymorphonuclear neutrophils (PMNs) that respond to activated complement may cause leukocyte emboli to remain in the lungs causing pulmonary dysfunction, leading to adult respiratory distress syndrome (ARDS). Aggregated PMN activity can be detected in complement-activated plasma, which reflects C_ (5a) concentration. The authors studied 61 patients. Each case had non-thoracic injuries, fungism, Gram-negative bacteremia or hypotension for more than 2 hours, and blood was collected to measure the polymerisation of PMN. Results 61 cases of ARDS occurred in 33 cases. The hazard ratio observed was 0.54. The risk factors for ARDS were sepsis, hypotension, trauma, drug poisoning and burns. Polymerisation in plasma PMN