自1976年Trager等首次报道恶性疟原虫红内期体外连续培养成功之后,我国高敏新等也相继报道培养成功。这一方法的建立为体外筛选抗疟药提供了可能性。近年来国内已采用这一模型测定了恶性疟原虫FC-Cl株对氯喹、青蒿素等药物的敏感性。但对其它常用抗疟药如乙氨嘧啶、奎宁、伯喹等的敏感性测定尚未见报道。我们参照管惟滨法进行了这一研究,现报告如下。材料和方法一、虫株 FCC-1株系1077年自海南岛一恶性疟 Since Trager et al. First reported in vitro continuous culture of Plasmodium falciparum in vitro in 1976, the success of this new high-sensitive strain was also reported in succession. The establishment of this method offers the possibility of screening anti-malaria drugs in vitro. In recent years, this model has been used to determine the susceptibility of Plasmodium falciparum FC-Cl strains to chloroquine, artemisinin and other drugs. However, the sensitivity of other common anti-malarial drugs such as pyrimethamine, quinine and primaquine has not been reported yet. We refer to pipe Weibin law conducted this study, are as follows. Materials and methods First, strains of strain FCC-1 1077 from Hainan Island a falciparum malaria