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目的:探讨充血性心力衰竭(CHF)患者血浆内皮素(ET)、降钙素基因相关肽(CGRP)和肿瘤坏死因子-α(TNF-α)的变化关系及其对LVMI和MWS的影响。方法:对入选的121例CHF患者测定了血浆ET、CGRP和TNF-α水平,超声心动图测量左室射血分数(LVEF),评价心功能;计算LVMI和MWS;同时选择27例正常人作为对照组。结果:CHF患者CGRP水平低于正常对照组,而血浆ET、TNF-α水平以及MWS和LVMI高于对照组(P<0.01);随着心功能恶化,CGRP水平逐渐降低,而血浆ET、TNF-α水平以及MWS和LVMI逐渐升高;CHF患者MWS和LVMI与CGRP水平呈负相关,而与血浆ET、TNF-α水平呈正相关(P<0.01)。结论:CHF患者ET、CGRP和TNF-α水平参与了CHF心室重构病理生理发生发展过程。
Objective: To investigate the changes of plasma endothelin (ET), calcitonin gene related peptide (CGRP) and tumor necrosis factor-α (TNF-α) in patients with congestive heart failure (CHF) and their effects on LVMI and MWS. Methods: The levels of plasma ET, CGRP and TNF-α were measured in 121 CHF patients. The left ventricular ejection fraction (LVEF) was measured by echocardiography and the cardiac function was evaluated. LVMI and MWS were calculated. At the same time, 27 normal subjects Control group. Results: The levels of CGRP in CHF patients were lower than those in normal controls, while the levels of plasma ET, TNF-α, MWS and LVMI were higher in CHF group than those in control group (P <0.01) -α and MWS and LVMI gradually increased. The MWS and LVMI of CHF patients were negatively correlated with CGRP levels and positively correlated with plasma ET and TNF-α levels (P <0.01). Conclusion: The levels of ET, CGRP and TNF-α in CHF patients are involved in the pathogenesis of CHF.